4SC starts phase 2 trial in hepatocellular carcinoma with 4SC-201 4SC AG.

4SC starts phase 2 trial in hepatocellular carcinoma with 4SC-201 4SC AG, the German drug discovery and development company, today announced the dosing of the initial patient in its Stage II trial with 4SC-201 , a pan-histone deacetylase inhibitor, as a fresh potential treatment option for patients with advanced hepatocellular carcinoma , the most frequent type of liver cancer. This proof-of-concept research will evaluate 4SC-201 as a second line therapy in this indication, for which only a single first line therapy medication is currently approved www.medicine-rx.com . The ‘Shelter’ research, entitled ‘A proof-of-concept Phase II study to evaluate efficacy, safety and pharmacokinetics of 4SC-201 and of the procedure combination of sorafenib plus 4SC-201 in sufferers with hepatocellular carcinoma exhibiting progressive disease under sorafenib treatment’, will examine whether treatment with 4SC-201 alone or in conjunction with sorafenib , the existing standard of care and attention in advanced HCC), can induce progression free survival and tumour responses in HCC patients who screen progressive disease under treatment with sorafenib.

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