About Trofile, a patient selection Trofile coreceptor tropism assay whether a patient with a strain of HIV to provide to provide either the CCR5 co-receptor, the CXCR4 coreceptor, or a combination of CCR5 and CXCR4 intended infected cells. CCR5 CCR5, CXCR4 or both coreceptors defines tropism of the virus strain. Trofile amplifies the envelope gene from a patient’s HIV genome and then uses it to make HIV particles containing the patient’s virus envelope protein pills for male ed . Obtained HIV particles are then cells containing cells containing the co-receptor CCR5 or CXCR4, the co – receptor on the cell surface. Once the virus infects the cells, it undergoes a single round of replication. Virus replication for the production of luciferase from a luciferase gene, which is performed in the cell by the virus. Forward-Looking Statements of luciferase in either CCR5 cells, cells, or both cell types CXCR4 coreceptor tropism of the patient defines the virus. Trofile is the only clinically validated tropism test and was used to select patients in all phase II and III trials of CCR5 antagonists to date.
Monogram Trofile assay was used to select patients for participation in clinical trials that formed the basis of the authorization Selzentry and in every advanced CCR5 inhibitor development program is used currently in progress. Besides the demand for tropism testing to for CCR5 for CCR5 inhibitor therapy, confirm the new DHHS guidelines, the potential benefits of testing following CCR5 inhibitor treatment failure, to determine if the patient is HIV have experienced a shift in viral tropism during treatment. The DHHS guidelines recommend Once the virushroughput phenotypic assays for co-receptor CCR5 testing for drugs at that time can be used seen and that genotypic assays. During the investigation, which is currently not available in stores.
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Argos Therapeutics announced today the publication an article in the online publication BMC Molecular Biology assistance novel method to novel method of stimulation of the CD40 receptor signal transduction by dendritic cells DCs), the potentially to improving the potency of their DC – based immunotherapy. Argos process involves electroporation of RNA to DCs, encoding an modified version of the T-cell protein of CD40L. Stimulate the receptor signal is cascade through ectopic expression of of this novel CD40L RNA leads secretion of the the downstream inflammatory cytokine IL-12 of the electroporated DCs. This new approach is has member the company Arcelis technology, a proprietary platform to the production of personalized immune therapies on HIV, any other infectious disease and cancer.