Even the most aggressive treatment with statin drugs fails to prevent coronary artery disease.

Ultrasound can be used to gauge the thickness of the arterial walls of the normal carotid artery, carotid bifurcation and the inner carotid artery to reach at CIMT, which is generally accepted to be a predictor of coronary atherosclerosis. Study results showed that the CETP inhibitor torcetrapib led to unparalleled increases of HDL-C and robust reduces of LDL-C but despite this had no benefit on atherosclerosis progression while one secondary endpoint of the analysis even recommended progression of disease in torcetrapib-treated sufferers. Also, torcetrapib significantly raised blood pressure, but the negative results of the RADIANCE trials could not be explained by this undesirable side-effect.Third, we didn’t record findings regarding myocardial salvage, microvascular obstruction, or biochemical variables in the registry. Finally, deviations from the randomly assigned treatment happened, although infrequently, and information about the reasons had not been available. A comparison of the clinical characteristics and outcomes between the sufferers who underwent randomization and the ones who did not indicates that the two cohorts differed significantly in a number of respects, especially in mortality at thirty days . In many cases, these variations reflect the exclusion from the trial of sufferers who had been ineligible because they were unable to provide oral consent.