In Nature Genetics

In Nature Genetics . For Second-Most Common Form Of Early – Onset Dementia Examining brain tissue from over 500 individuals in 11 countries, researchers found from the University of Pennsylvania School of Medicine and the Children’s Hospital in Philadelphia and his colleagues have a new risk factor for second-most – common cause of early-onset dementia after Alzheimer’s disease.

Play ‘By identifying genetic variants that play a role in the development and progression of one type of FTLD can, this research, if replicated, a step closer to involved understand the complex biological pathways in this devastating disease, said Marcelle Morrison – Bogorad, director of the National Institutes of Health Division of Neuroscience. The findings build on a 2006 discovery by co-senior authors Virginia Lee, director of the Center for Neurodegenerative Disease Research, and John Q. Trojanowski, director of the Institute of Aging at Penn -. They led an international team that found that a protein called TDP-43 accumulates abnormally in brain tissue from patients with a type of hereditary FTLD Several functions TDP-43 is a known protein is expressed throughout the body. Several functions, including the regulation of transcription of the genetic code and as scaffolding for nuclear and motor neuron proteins.

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