A complete of 182 randomly designated patients died or had progression to ESRD , and 143 exited the study before it had been closed . Baseline characteristics in both groups were similar . The median urinary albumin-to-creatinine ratio was 847 at enrollment; 662 individuals experienced a urinary albumin-to-creatinine ratio of 1000 or higher. Fewer individuals in the combination-therapy group than in the monotherapy group could actually reach the entire target dosage of lisinopril or placebo ; 89.6 percent of the sufferers in the combination-therapy group and 93.4 percent of the individuals in the monotherapy group were acquiring at least 10 mg of lisinopril or placebo per day at the end of the dose-adjustment period... Adelaide researchers identify key protein involved with ‘super-inflammatory’ immune response Researchers have got made another important step in the progress towards being able to block the advancement of multiple sclerosis and other autoimmune diseases. Published today in the journal Nature Communications, the researchers at the University of Adelaide possess identified an integral protein involved in a 'super-inflammatory' immune response that drives the progression of MS and various other autoimmune diseases.