Andrew C. Chen, M uses .B., B.S., Andrew J. Martin, Ph.D., Bonita Choy, M.Med.D., Robyn A. Dalziell, Ph.D., Catriona A. McKenzie, M.B., B.S., Richard A. Scolyer, M.D., Haryana M. Dhillon, Ph.D., Janette L. Vardy, M.D., Anne Kricker, Ph.D., Gayathri St. George, M.Sc.Med., Niranthari Chinniah, M.B., B.S., Gary M. Halliday, D.Sc., and Diona L. Damian, Ph.D.: A Stage 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention Nonmelanoma skin cancers, mainly basal-cell carcinomas and squamous-cell carcinomas, will be the most common cancers in white populations.1 In Australia, nonmelanoma epidermis cancers are four occasions as common as all other cancers combined,2,3 and in america, the annual total cost of treating nonmelanoma skin cancers is estimated to be $4.8 billion.4 Basal-cell carcinomas metastasize but are locally invasive and can be disfiguring rarely.5 Squamous-cell carcinomas, specifically less well-differentiated tumors on the top and neck, have metastatic potential and may result from premalignant actinic keratoses.6 Nonmelanoma skin cancers and actinic keratoses are caused primarily by exposure to ultraviolet radiation.7 The usage of sunscreens can reduce the incidence of squamous-cell carcinoma8 and actinic keratosis9 and may also decrease the incidence of basal-cell carcinoma and melanoma after prolonged use.10 However, adherence to the application of sunscreens is suboptimal often, among high-risk persons actually.11 The increasing incidence of nonmelanoma epidermis cancer worldwide14 highlights the need for additional preventive measures.
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