The technique uses double-stranded DNA to immediate the behavior of various other molecules.

Of manipulating DNA only into such shapes Instead, the researchers are employing DNA to regulate the folding and resulting structure of RNA. Eventually, they envision building supramolecular devices whose internal workings are governed by twisted strands of DNA. In a paper that has been recognized for publication in the Journal of the American Chemical Society, and submitted on its Web site, Silverman and graduate pupil Chandrasekhar Miduturu start out with a piece of unfolded RNA. Through specific chemical reactions, they connect two strands of DNA, each resembling one side of a ladder. The two DNA strands spontaneously bind jointly, then the researchers add magnesium ions to initiate folding of the RNA.Far in 2015 Thus, the number of new publications has exceeded 150 already, more than the total amount of publications from all the previous years combined, signaling acceleration in technology adoption. Chief Scientific Officer, Dr. Xiao-Jun Ma, commented: This rapid upsurge in publications speaks right to the value of RNAscope technology in lots of fields of research. Spatially mapped single-cell gene expression data are crucial to understanding the development, function and structure of complex tissues in the molecular and cellular level. However, obtaining such data has been a huge bottleneck because of technical problems of traditional RNA ISH methods and the increased loss of contextual details with grind-and-bind assays. With RNAscope, such data can be generated within weeks from an idea to publication quality images.

PRESS RELEASE Statement related to: Steven J.