This generally occurs when the bladder muscles function involuntarily. This disease could be in either moderate or chronic form. Mild incontinence is definitely when it happens in rare occasions and chronic is usually when leakage of urine occurs on a frequent basis. When is normally urine incontinence chronic? There are varied causes because of its chronic phase: Weak pelvic muscles. Highly active bladder muscles. Heavy damage caused to nerve which resulted in malfunction of bladder control. Side effects caused due to surgery. There are various kinds of this disease, and the most common ones are tension incontinence, overactive bladder. Stress incontinence occurs when there’s been urine leakage triggered due to pressure or unexpected muscle mass contraction.The X chromosome-linked form of the syndrome happens only in men and is the effect of a mutation in the MID1 gene. It is estimated to have an effect on between one in 50,000 to 100,000 men. Incidence of the autosomal dominant type of the disorder is normally unknown. This syndrome is approximated to occur in one in 800,000 to 1 1 million people. A mutation in the MED12 gene and six regions of the X chromosome have already been linked to FG syndrome. Although the prevalence of the disorder is not known, only many hundred cases have been reported world-wide. Amid his landmark work that began in the 1960s and that has continued for years, Opitz founded the American Journal of Medical Genetics in 1976 also, becoming its first editor-in-chief and remaining in that position until 2001.